Corneal Neurotization

This innovative technique involves the delicate process of reinnervating the cornea by connecting sensory nerves from nearby tissues to the cornea, which may have lost sensation due to injury, disease, or surgical procedures.

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What Is Corneal Neurotization And Who Needs It?

People who have experienced loss of sensation through the 5th cranial nerve (called, the trigeminal nerve) are prone to having loss of sensation to the delicate cornea of the eye. This is the colored portion of the eye and where vision occurs. When this happens, the ability to protect the eye by way of the blink reflex is lost. In the past, this led to irreversible blindness due to progressive scarring of the cornea. Corneal neurotization is a sophisticated procedure designed to restore sensation and reverse vision-impairing scarring of the eye (called neurotrophic keratopathy) by delivering sensation to the affected cornea.

How Is Corneal Neurotization Performed?

Corneal neurotization requires one side of the face to be unaffected in order to borrow the nerve supply. A nerve graft is harvested from the leg, called the sural nerve. This nerve only provides a small amount of sensation to the top and outer part of the foot. Therefore, sacrificing it does not lead to any lasting disability. Simultaneously, the area of the eyebrow on the unaffected side is prepared by isolating a branch of the trigeminal nerve, called the supratrochlear nerve. This becomes our donor nerve. Small incisions are then placed in the upper eyelid crease on both sides to pass the nerve graft underneath the skin. The sural nerve graft is then carefully divided into smaller branches and stitched underneath the outer lining of the sclera (called conjunctiva). This is done around the entire cornea. On the donor nerve side, the sural nerve graft is stitched to the side of the supratrochlear nerve and will gain innervation from it over time.

How Long Does It Take To See The Effects Of Corneal Neurotization?

It takes approximately 9-12 months for the nerve input to pass through the graft and into the cornea. Benefits can be seen for several years thereafter.

Is Corneal Neurotization Dangerous?

All surgeries carry some risk. However, corneal neurotization has a very low risk of damaging the eye further. Scars tend to heal unnoticeably, and there is no discernible loss of sensation from using either the sural nerve or the supratrochlear nerve.

What Is The Recovery From Corneal Neurotization Like?

Recovery from corneal neurotization is relatively straightforward. Patients may walk immediately after surgery and can even go home the same day. Dr. Panossian will provide additional instructions on caring for the surgical areas. Generally, there is to be no aggressive physical activity or heavy lifting for 4-6 weeks. Rubbing of the incisions is discouraged. Patients are encouraged to shower on the first postoperative day. Pain is also minimal. You will be given pain medications and eye lubricant prior to going home.

What Are The Risks And Complications Of Corneal Neurotization?

Perhaps the greatest complication of corneal neurotization is inadvertent damage of the eye itself. This is a very rare phenomenon. Another issue may be poor re-innervation of the cornea despite normal healing. If this were to happen, then there would be no discernible change in corneal sensation from preop.

Additional risks are quite minor and include typical risks of any surgery. This includes bleeding, infection, poor scarring, and anesthesia difficulties. Preoperative assessment by a qualified primary care doctor usually will suffice prior to undergoing surgery in order to minimize complications.

Dr. Panossian is internationally-recognized for his work in facial paralysis and corneal neurotization. He is an expert in microsurgery and peripheral nerve surgery, which are vital to the success of this very unique procedure. If you are experiencing corneal sensitivity issues, please contact us today to immediately schedule a consultation.

Why choose Dr Panossian

He received his medical education at Tufts University School of Medicine.
Graduated at the top of his class at UCLA, receiving Phi Beta Kappa and Summa Cum Laude honors.
Was accepted into an elite combined general surgery and plastic surgery residency at the Keck School of Medicine of USC.
Completed subspecialty training in craniofacial surgery at the Hospital for Sick Children in Toronto and Harvard Medical School.
Was mentored by Dr. Ron Zuker in the practice of facial paralysis reconstruction. This prestigious fellowship position was available to only one surgeon in the United States.
Is affiliated with various charitable and educational organizations, including Operation Smile and Mending Kids.
Is a member of the American Society of Plastic Surgeons and the highly selective American Association of Plastic Surgeons, reserved for only a select group of individuals nationally who have demonstrated excellence in academic plastic surgery.
Holds memberships in several other professional societies including the American College of Surgeons and the American Society of Reconstructive Microsurgery.
He serves on the Board of Directors for Mending Kids and the Gondobay Manga Foundation, a non-profit organization dedicated to the improvement of lives in Sierra Leone.
Has been nominated by his peers annually since 2012 as a “Super Doctor.”
Served as an expert medical consultant and appeared on The Doctors, Grey’s Anatomy, and Nip/Tuck.
Has been featured as “Top Doctor” in US News and World Report, Pasadena Magazine, and Los Angeles Magazine.

- Real Patient

"My experience with doctor Panossian was beyond amazing! he was very informative and professional He took his time and professionaly explained each of my questions. I’m that type of person who asks a lot of questions and he was very happy answering all of them."